The Bioprocess
The Bioreactor
Our Wave Bioreactor is a growth platform we use to generate recombinant cells under controlled conditions using predictable levels of oxygen, pH and other critical parameters. For greater efficiency, we use a bag-based system rather than steel containers. While the culture time is essentially the same, the sterile and disposable cellbags are much simpler to use because they require no maintenance and eliminate the potential for contamination between cultures. In addition, this approach is more flexible and requires fewer staff, which allows us to handle smaller, customized cell-culture production for our own use or out-sourcing production to other companies.
Down-stream processing
Downstream of the Wave bioreactor, we use the ÄKTAexplorer chromatographic system to purify our active pharmaceutical ingredients.
With the ÄKTAexplorer we are capable of rapidly developing and optimizing purification strategies for a broad array of biomolecules in a multi-step, high-throughput fashion.
In our processes, the ÄKTAexplorer serves an important tool for the initial capture and isolation of the active pharmaceutical ingredient from the culture medium as well as in subsequent purification steps to ensure the production of biomolecules to the highest possible purity.
Pre-clinical research
Our leads based on purified mucin-type fusion proteins with tailored O-glycan substitution are structurally and functionally validated using different analytical techniques as well as various cell-based in vitro assays and in vivo disease models.